Methorexate drug survival rate is low in psoriasis patients

[tdjclarke]

Thanks for the info, great stats.   

There has to be better solutions with these types of numbers!  It was more than the physical side effects, it was starting to affect my state of mind too. 

I just stopped after 3 weeks of 25mg MTX.  My life was taking too much of a turn due to the side effects.  For now drug free, but a new Mousse call Enstilar is making a big difference on my psoriasis.  Is it a combination of both?  We'll find out in a while.

For now Methotrexate is out for me.  Slowly getting my life back together.

Many have suggestions, which I have noted.  From my short experience in this club, you try remedies, until you find the right one(s) for you.

Cheers

[Fred]

Many have suggestions, which I have noted.  From my short experience in this club, you try remedies, until you find the right one(s) for you.

Yep and when you do find one hold onto it as long as possible as there is a chance it will fail you sometime in the future.

I'm sure Bill will disagree with that statement, but there are not many people that get past 5 years on the same treatment. Longest time on a successful treatment for psoriasis

[jiml]

Methotrexate was the same for me , but I’ve now had six good years on Fumaderm flake and pain free
As Fred says keep looking until you find the right one for you ... but you did the right thing dumping the methotrexate in my opinion  

[Moxtina]

Just to chime in, a bit late to the game, I think....

if you have the MTHFR genetic polymorphism, you should NEVER take methotrexate. An estimated 30-60% of the population has this folate absorption/methylation disorder and many do not even know it. There's a strong intersection between autoimmune disease and MTHFR. I recently had the test done and found that I was positive for the condition and that it explains a lot of my health issues. If you have the means, do it!

Those with MTHFR have varying degrees of problems metabolizing folate. Methotrexate works by interfering with the body's use of folate (or, as you might know it, folic acid - the synthetic, cheaper, more popular version of FOLATE) a nutrient needed for cell growth. This causes problems, as you might imagine! We need ALL the B vitamins to live.

Methotrexate can cause serious issues, or simply fail to be effective (on the less extreme side), especially in those with the MTHFR C677T polymorphism. There is increased risk of MTX-induced hepatic and gastrointestinal toxicities and increased risk of severe mucositis and hematological toxicity. According to one paper I read on the topic, the MTHFR A1298C polymorphism was *not significantly associated with hepatic and hematological toxicity, however, the MTHFR C677T polymorphism is correlated with MTX toxicity via blood and other types of cancers.

There are some great websites that discuss this genetic issue and many articles from studies done on the effects of MTX/MTHFR.

Moxie

[Turnedlight]

Just to chime in, a bit late to the game, I think....

if you have the MTHFR genetic polymorphism, you should NEVER take methotrexate. An estimated 30-60% of the population has this folate absorption/methylation disorder and many do not even know it. There's a strong intersection between autoimmune disease and MTHFR. I recently had the test done and found that I was positive for the condition and that it explains a lot of my health issues. If you have the means, do it!

Those with MTHFR have varying degrees of problems metabolizing folate. Methotrexate works by interfering with the body's use of folate (or, as you might know it, folic acid - the synthetic, cheaper, more popular version of FOLATE) a nutrient needed for cell growth. This causes problems, as you might imagine! We need ALL the B vitamins to live.

Methotrexate can cause serious issues, or simply fail to be effective (on the less extreme side), especially in those with the MTHFR C677T polymorphism. There is increased risk of MTX-induced hepatic and gastrointestinal toxicities and increased risk of severe mucositis and hematological toxicity. According to one paper I read on the topic, the MTHFR A1298C polymorphism was *not significantly associated with hepatic and hematological toxicity, however, the MTHFR C677T polymorphism is correlated with MTX toxicity via blood and other types of cancers.

There are some great websites that discuss this genetic issue and many articles from studies done on the effects of MTX/MTHFR.

Moxie

I presume that’s why you always take folic acid alongside mtx?

We do not get that kind of diagnostic test as standard but if it was that dangerous for a certain portion of the population to take mtx, I imagine they just wouldn’t risk it.

As it is on the NHS, we try things out, if they work and we’re happy then all good, if they don’t work or we have side effects, we move on. I imagine this approach is (currently) cheaper than gene profiling.