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Published in The British Journal of Dermatology this study looks at the effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis.
Background:
Evidence on the effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis is low and only based on retrospective data. Best results are achieved in a time consuming day-care setting.
Objectives:
To prospectively study the effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis. In addition, the effectiveness, safety, duration of treatment and number of visits between regular day-care and day-care with telemedicine were compared.
Methods:
Data were collected from the prospective observational Child-CAPTURE registry of children with psoriasis. Effectiveness was analyzed by mean percentage improvement in Psoriasis Area and Severity Index (PASI). Safety was assessed by recording adverse events. Number of visits and duration of treatment were reported.
Results:
For all patients a mean percentage reduction in PASI score of -69.3% was found, with no significant differences between regular day-care and day-care with telemedicine. The only adverse event reported was irritation of the skin. Both the frequency of irritation during treatment as well as the mean duration of treatment did not significantly differ between the two groups. Patients with telemedicine had significant less number of visits
Conclusion:
This first prospective observational study demonstrated that short-contact dithranol therapy in paediatric psoriasis is effective and safe. Regular day-care and day-care with telemedicine are both equally effective. Telemedicine can be of additional value as it is less time consuming. Hopefully, it will therefore make dithranol treatment appropriate for a larger group of children with psoriasis.
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Background:
Evidence on the effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis is low and only based on retrospective data. Best results are achieved in a time consuming day-care setting.
Objectives:
To prospectively study the effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis. In addition, the effectiveness, safety, duration of treatment and number of visits between regular day-care and day-care with telemedicine were compared.
Methods:
Data were collected from the prospective observational Child-CAPTURE registry of children with psoriasis. Effectiveness was analyzed by mean percentage improvement in Psoriasis Area and Severity Index (PASI). Safety was assessed by recording adverse events. Number of visits and duration of treatment were reported.
Results:
For all patients a mean percentage reduction in PASI score of -69.3% was found, with no significant differences between regular day-care and day-care with telemedicine. The only adverse event reported was irritation of the skin. Both the frequency of irritation during treatment as well as the mean duration of treatment did not significantly differ between the two groups. Patients with telemedicine had significant less number of visits
Conclusion:
This first prospective observational study demonstrated that short-contact dithranol therapy in paediatric psoriasis is effective and safe. Regular day-care and day-care with telemedicine are both equally effective. Telemedicine can be of additional value as it is less time consuming. Hopefully, it will therefore make dithranol treatment appropriate for a larger group of children with psoriasis.
Source: NO LINKS ALLOWED