Methotrexate for psoriasis review

[D Foster]

I am going to have to disagree - I have read enough articles to suggest the actual % of liver problems is 15 to 25. Now, that is not counting alcohol use, but that would be nearly impossible to rule out. That means as many as a quarter of people who take it long term will have some sort of liver problems. My rheumatologist says most people get about four years on the drug and need to switch because of complications.

The problem is that some of those people ,by the law of averages , will have liver problems to start with even though they have been tested so the percentage is not as high, they also may be taking other drugs as well. What sort of problems will a quarter have because if that is including side effects then yes but that is not quite the same as saying that a quarter will have liver problems ,it will be a much smaller number.
I am not defending MTX I am just saying that a lot of the so called evidence is not really that good as you can rely on it as gospel it's more anecdotal.

[mataribot]

Why don't we see these increases is other medications for psoriasis?

[D Foster]

Why don't we see these increases is other medications for psoriasis?

I think that MTX has been used for P/PsA as long or probably longer than most other drugs , the more people on it then the more that are going to have problems and it's also been used for RA for even longer.