IL-17 plasma levels and psoriasis study

[Fred]

This meta-analysis evaluated IL-17 levels in patients with psoriasis. IL-17 is targeted by the new bio's:
Cosentyx (secukinumab) and Taltz (ixekizumab)

Quote:

---

Background:
Emerging evidence indicates that plasma interleukin (IL)-17 levels may be associated with increased risk of psoriasis, but the individual published results are inconclusive.

Aim:
To evaluate IL-17 levels in patients with psoriasis using a meta-analysis of studies comparing IL-17 levels in controls and in patients with psoriasis.

Methods:
All relevant studies were identified by searching pub med, Web of Science and MEDLINE databases before 1 November 2015. Pooled risk estimates were calculated by random-effects models. Crude OR and standardized mean difference (SMD) with corresponding 95% CI were also calculated.

Results:
In total, eight cross-sectional study studies were included in the final analysis. The mean plasma levels of IL-17 were higher in patients with psoriasis than in healthy controls (SMD = 0.47, 95% CI = 0.07–0.86, P < 0.001).

Conclusions:
Based on this literature review, there appears to be a positive association between IL-17 plasma levels and psoriasis.

Source: onlinelibrary.wiley.com

*Early view funding unknown.

[jiml]

So it seems the three bios targeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  


Edit to correct spelling

[Fred]

So it seems the three bios fptargeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is but yes it seams the future of psoriasis treatment is the Bio's.

[jiml]

So it seems the three bios targeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is    but yes it seams the future of psoriasis treatment is the Bio's.

It's my fat fingers

[Fred]

So it seems the three bios targeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is    but yes it seams the future of psoriasis treatment is the Bio's.

It's my fat fingers

Good job you don't have psoriatic arthritis in them.

[jiml]

So it seems the three bios fptargeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is    but yes it seams the future of psoriasis treatment is the Bio's.

And DMF which also targets IL-17 I believe

[Fred]

So it seems the three bios fptargeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is    but yes it seams the future of psoriasis treatment is the Bio's.

And DMF which also targets IL-17 I believe  

Oh that Old stuff

[Caroline]

So it seems the three bios fptargeting IL-17 levels are on the right track,  as the evidence of the efficacy would seem to confirm  

I don't know what an "fptargeting" is    but yes it seams the future of psoriasis treatment is the Bio's.

And DMF which also targets IL-17 I believe  

Oh that Old stuff  

This only proves it was far ahead of its time, it still is as it even does more, and it is way cheaper than the Bio's, which is irrelevant if it is paid for, but becomes very relevant if it's not.

[Fred]

This only proves it was far ahead of its time.

Yes a bit like telephones with cables, or motorcars we had to start with a handle.

I'll let you have the last word as you will anyway, but I'll zip it as I know where we will take this thread next.