Interleukin 17 treatments for psoriasis efficacy and safety study

[Fred]

This study evaluated the efficacy and safety of Interleukin 17 treatments for psoriasis. *Cosentyx and Taltz are Interleukin 17 treatments.

Quote:

---

Background:
The interleukin-17 (IL-17) cytokine pathway plays a key role in the development of psoriasis. Antibodies targeting IL-17 or blocking its receptor may be a new therapeutic approach for psoriasis. To assist treatment selection in daily practice, it is essential to understand the benefit and risk profile of IL-17 antagonists.

Objective:
We performed a meta-analysis to evaluate the efficacy and safety of IL-17 antagonists in patients with psoriasis.

Methods:
We searched a number of databases for relevant randomized controlled trials (RCTs) published before May 2016. The following outcomes were evaluated: Psoriasis Area and Severity Index (PASI) 75, 90, 100 response, Investigator's Global Assessment (IGA) score of 0 or 1 response, adverse events (AEs) and withdrawals. The meta-analysis was performed using Review Manager 5.2 software.

Results:
Nine RCTs with 5951 patients were included. IL-17 antagonists achieved higher PASI 75, 90, 100 response rates and Dermatology Life Quality Index 0 or 1 response rates than placebo and a lower incidence of discontinuations due to lack of efficacy. In the safety analysis, no significant differences were found between the IL-17 antagonists and placebo in the proportion of patients with serious AEs, cardiovascular disease and discontinuations due to AEs. However, IL-17 antagonists were associated with a higher proportion of patients with any AEs and infections than placebo.

Conclusion:
IL-17 antagonists were effective, with an acceptable safety profile, for patients with plaque psoriasis. Vigilance because of the potential for infection will be necessary for IL-17 antagonists.

Source: onlinelibrary.wiley.com

Conflicts of interest: The authors declare that they have no competing interests.

Funding sources: The authors received no payment in preparation of this manuscript.

Dan Wu and Si-Yuan Hou contributed equally to the work.

Cosentyx (secukinumab)

Taltz (ixekizumab)