Health Boards
This study looked at the relationship between genetic polymorphisms in the IL10 gene cluster and psoriasis.
Source: onlinelibrary.wiley.com
*Funding:
Estonian Science Foundation
Estonian Ministry of Science and Education
European Union Regional Development Fund
Estonian Ministry of Education and Research
Russian Foundation for Basic Research
Quote:
Background:
Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20 and IL-24 have been implicated in autoimmune diseases and we have previously reported that genetic variants in the IL10 gene cluster were associated with psoriasis.
Objectives:
To analyse the relationship between genetic polymorphisms in the IL10 gene cluster and psoriasis. This study also explores whether there are gene–gene interactions among these genetic polymorphisms.
Methods:
A total of 377 patients with psoriasis and 403 matched healthy controls were enrolled to carry out a case–control study for 48 single-nucleotide polymorphisms (SNPs) of the IL10 gene cluster. Genotyping for the SNPs was conducted on the Applied Biosystems 3730 DNA Analyzer using SNPlex® technology. Generalized multifactor dimensionality reduction (GMDR) analysis was applied to discover a likely gene–gene interaction model among the SNPs.
Results:
The results showed that the allele distributions of IL10 gene cluster SNPs are significantly different between the case and control groups. Carriers of the IL10 T allele (rs1554286) and the IL20 T allele (rs1400986) conferred protection from psoriasis [odds ratio (OR) = 0·63, corrected P-value (Pc) = 0·007; OR = 0·62, Pc = 0·038, respectively]. GMDR analysis displayed a significant gene–gene interaction between IL10 (rs1554286) and IL20 (rs1518108) variants. The strongest protective effect was found with the block 1 haplotype ACATA in the IL10 gene (Pc = 0·004).
Conclusions:
This study presents a novel finding that the combination of the two SNPs, IL10 (rs1554286) and IL20 (rs1518108), is associated with a reduced risk of psoriasis. Our results indicate that genetic variants of the immunomodulatory IL10 and IL20 genes may offer a protective effect in Europeans from Russia. Independent studies are required to verify the results and find a possible functional explanation.
Source: onlinelibrary.wiley.com
*Funding:
Estonian Science Foundation
Estonian Ministry of Science and Education
European Union Regional Development Fund
Estonian Ministry of Education and Research
Russian Foundation for Basic Research