Bill's pure dimethylfumarate thread

[Caroline]

Bill,
Just to check.
I found a study in the Netherlands. In the JOURNAL OF DERMATOLOGICAL TREATMENT, called:

Association of lymphopenia and eosinophilia with dimethylfumarate treatment efficacy and tolerability in psoriasis: a retrospective study

The study has been executed by two doctors from the Maxima Medics centre
Department of Dermatology, Maxima Medical Center Veldhoven, Veldhoven, The Netherlands

Quote:

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ABSTRACT

Background: Dimethylfumarate (DMF) is an effective treatment for psoriasis, which may cause side effects in a considerable group of patients. Alterations in white blood cell (WBC) counts may predict treat- ment success and the occurrence of side effects.
Objectives: To analyze WBC counts with respect to efficacy and the prevalence of side effects during DMF therapy for psoriasis.

Methods and materials: Psoriasis patients were treated with DMF. Retrospective data (WBC counts, treat- ment results, and side effects) were analyzed to assess correlations with respect to efficacy, tolerability, and leukocyte subsets.
Results: Of 95 patients treated with DMF, 60 patients (63.2%) had treatment success at week 16 and 77 patients (81.1%) experienced side effects. Absolute lymphocyte counts were more decreased in the treat- ment success group versus the treatment failure group: 1.1 (±0.7 SD) versus 0.6 (±0.6 SD); p<.05. Eosinophil counts were more increased in the group with side effects versus the group without side effects: 3.8 (±5.5 SD) versus 1.2 (±2.5 SD); p<.05. However, direct correlation studies showed no statistic- ally significant correlations.

Conclusions: Lymphopenia is associated with better clinical results of DMF treatment for psoriasis, whereas eosinophilia is associated with the occurrence of side effects.

It is this conclusion that is interesting for us DMF users.
If my interpretation is correct, then it says that if your lympho’s go down, then this means that the drug is effective for you. And in the second part, if your eosinophiles go up, you will experience more side effects.

Does this also fit for you ?

Cheers,
Caroline