Health Boards
Wed-12-02-2020, 17:22 PM
I was already waiting for your report on your visit. 
As you expected, it relatively clear that the Cosentyx is failing.
The eczema I don’t understand. That’s weird... eczema is an atopic disease and atopic diseases have the tendency to protect against arthritis.
It is from a study:
Decreased prevalence of atopic features in patients with psoriatic arthritis, but not in psoriasis vulgaris
Enes Hajdarbegovic, Tamar Nijsten, Anton Westgeest, Fred Habraken, Loes Hollestein, Bing Thio
J Am Acad Dermatol. 2013 Feb;68(2):270-7
ABSTRACT
Background: The prevalence of atopic disorders is reduced in patients with various au- toinflammatory diseases, but this association has not been studied in psoriasis vulgaris or psoriatic arthritis.
Objective: To compare the prevalence of hayfever, asthma and sensitization to common aeroallergens in patients with psoriasis vulgaris and patients with psoriatic arthritis to controls and to investigate whether atopy influences the arthritis activity and severity scores in psoriatic arthritis patients.
Methods: In a cross-sectional cohort study design, the differences in patient-reported lifetime prevalence of atopic disorders and serum immunoglobulin E directed against common aeroallergens were compared. The effect of atopy on arthritis severity was assessed using the Disease Activity Score 28 and Health Assessment Questionnaire. Logistic regression models were used to calculate crude and adjusted odds ratios with 95%-confidence intervals for presence of atopy.
Results: One hundred and sixty-eight patients with psoriatic arthritis, 133 psoriasis vulgaris patients and 147 controls were included. The life time prevalence of hayfever did not differ across groups. Patients with psoriatic arthritis were less likely to have suf- fered from asthma than controls; adjusted OR=0.20 [CI 95% 0.04-0.92] and they were less likely to be sensitized; adjusted OR=0.50 [95%CI 0.25-0.99]. HAQ-VAS for pain and HAQ-VAS for patient global score were significantly reduced by sensitization to common aeroallergens (beta-coefficient -0.54 [95% CI -0.84 - -0.25] and -18.4 [95% CI -28.5 - -8.25] respectively.)
Limitations : This is a cross-sectional, small numbered study.
Conclusion: Atopy may protect against development of psoriatic arthritis and diminish
its severity.
Key words
Atopy, asthma, hayfever, psoriatic arthritis, psoriasis vulgaris, life-time prevalence
Capsule summary
The prevalence of atopic disorders is diminished in rheumatoid arthritis.
The prevalence of atopic disorders is also diminished in patients with psoriatic arthritis. Atopy may be a risk determinant and a severity predictor for psoriatic arthritis.
Not that it will help you, but it seems a bit odd.
I read it in an article in the Dutch magazine of the Dutch patiënt Organization.
Anyway, you are going to try tremfya, the next step. Who knows what it will bring. I will give my best hopes for you.
As you expected, it relatively clear that the Cosentyx is failing.
The eczema I don’t understand. That’s weird... eczema is an atopic disease and atopic diseases have the tendency to protect against arthritis.
It is from a study:
Decreased prevalence of atopic features in patients with psoriatic arthritis, but not in psoriasis vulgaris
Enes Hajdarbegovic, Tamar Nijsten, Anton Westgeest, Fred Habraken, Loes Hollestein, Bing Thio
J Am Acad Dermatol. 2013 Feb;68(2):270-7
ABSTRACT
Background: The prevalence of atopic disorders is reduced in patients with various au- toinflammatory diseases, but this association has not been studied in psoriasis vulgaris or psoriatic arthritis.
Objective: To compare the prevalence of hayfever, asthma and sensitization to common aeroallergens in patients with psoriasis vulgaris and patients with psoriatic arthritis to controls and to investigate whether atopy influences the arthritis activity and severity scores in psoriatic arthritis patients.
Methods: In a cross-sectional cohort study design, the differences in patient-reported lifetime prevalence of atopic disorders and serum immunoglobulin E directed against common aeroallergens were compared. The effect of atopy on arthritis severity was assessed using the Disease Activity Score 28 and Health Assessment Questionnaire. Logistic regression models were used to calculate crude and adjusted odds ratios with 95%-confidence intervals for presence of atopy.
Results: One hundred and sixty-eight patients with psoriatic arthritis, 133 psoriasis vulgaris patients and 147 controls were included. The life time prevalence of hayfever did not differ across groups. Patients with psoriatic arthritis were less likely to have suf- fered from asthma than controls; adjusted OR=0.20 [CI 95% 0.04-0.92] and they were less likely to be sensitized; adjusted OR=0.50 [95%CI 0.25-0.99]. HAQ-VAS for pain and HAQ-VAS for patient global score were significantly reduced by sensitization to common aeroallergens (beta-coefficient -0.54 [95% CI -0.84 - -0.25] and -18.4 [95% CI -28.5 - -8.25] respectively.)
Limitations : This is a cross-sectional, small numbered study.
Conclusion: Atopy may protect against development of psoriatic arthritis and diminish
its severity.
Key words
Atopy, asthma, hayfever, psoriatic arthritis, psoriasis vulgaris, life-time prevalence
Capsule summary
The prevalence of atopic disorders is diminished in rheumatoid arthritis.
The prevalence of atopic disorders is also diminished in patients with psoriatic arthritis. Atopy may be a risk determinant and a severity predictor for psoriatic arthritis.
Not that it will help you, but it seems a bit odd.
I read it in an article in the Dutch magazine of the Dutch patiënt Organization.
Anyway, you are going to try tremfya, the next step. Who knows what it will bring. I will give my best hopes for you.