Health Boards
Wed-21-03-2012, 20:01 PM
My dermatologist has spoken to me about testing a new treatment she said it was a JAK inhibitor. I have found this
I can't find any info, and she said she couldn't give me much more as it's still in trial and her professor would have to contact me to discuss it.
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway which transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell. The JAK-STAT system is a major signaling alternative to the second messenger system.
The JAK-STAT system consists of three main components: a receptor Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT).
The receptor is activated by a signal from interferon, interleukin, growth factors, or other chemical messengers. This activates the kinase function of JAK, which autophosphorylates itself (phosphate groups act as "on" and "off" switches on proteins). The STAT protein then binds to the phosphorylated receptor. STAT is phosphorylated and translocates into the cell nucleus, where it binds to DNA and promotes transcription of genes responsive to STAT.
So anyone got any info on JAK inhibitors please?
Quote:Emerging clinical research has demonstrated the integral role of Janus kinase (JAK) proteins in the pathogenesis of psoriasis. As of 2010, two new oral JAK inhibitor drugs, ruxolitinib and tofacitinib (formerly called tasocitinib), have shown rapid and promising efficacy in Phase I/II trials with patients showing significant skin clearing within one week of beginning treatment. Ruxolitimib has completed Phase II clinical trials supplied as a topical cream.however she said it was an injection under the skin like the bio's
I can't find any info, and she said she couldn't give me much more as it's still in trial and her professor would have to contact me to discuss it.
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway which transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell. The JAK-STAT system is a major signaling alternative to the second messenger system.
The JAK-STAT system consists of three main components: a receptor Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT).
The receptor is activated by a signal from interferon, interleukin, growth factors, or other chemical messengers. This activates the kinase function of JAK, which autophosphorylates itself (phosphate groups act as "on" and "off" switches on proteins). The STAT protein then binds to the phosphorylated receptor. STAT is phosphorylated and translocates into the cell nucleus, where it binds to DNA and promotes transcription of genes responsive to STAT.
So anyone got any info on JAK inhibitors please?