JAK (Janus Kinase) Inhibitors

[Fred]

Hi Fred,

I could give you plenty of info on the biochemical/cellular roles of the JAK/STAT pathways that are involved in gene regulation and cellular growth but I am assuming the info you are looking for is regarding medical treatment with the inhibitors of which I know very little.

What I do know is that JAK is involved in cellular proliferation (multiplication) and to inhibit it would lead cells to undergo apoptosis (programmed cell death) which is one of the processes that is believed to have gone wrong in psoriasis as the cells keep growing and dividing at a higher rate than normal skin cells.

I can give you more info on the processes it's involved in if you'd like but as to medical uses I believe it's really only been used as a camcer therapy.

Krissie

Hello Krissie, Sorry I forgot you know about microbiology, what an asset for Psoriasis Club. I would like to know more, I understand the TNF blockers but have never heard of JAK till today.