Health Boards
Wed-02-11-2022, 23:54 PM
(This post was last modified: Wed-02-11-2022, 23:59 PM by mataribot. Edited 4 times in total.)
Most biologics last around 2 - 3 years. I think your problem may be the fact that your body is use to the IL-23 blocker. I hate how most of the new drugs are SSDD. There hasn't been anything new for PSA in a while. There are a few new ones for psoriasis, but I don't think any of them have been approved for PSA.
On another note, I wouldn't count out the IL-17 blockers just because of Cosentyx. Consentyx is a weight based drug without a weight based dose. Taltz out performed in longevity, but still fails around the 3 year mark.
I agree with staying away from NSAIDs. There evidence to support (from small trials) that long term use of NSAIDs leads to faster joint replacements in people with OA. While these studies have nothing to do with PSA, but it does suggest masking the pain isn't always a good thing. I hope I don't violate the forum rules with copying a piece of that study here...
"...Our study demonstrated that compared to the non-users, NSAID users have a higher risk of knee arthoplasty. This may be because NSAIDs users had a lower perception in joint pain and disease activity, resulting in poor joint protection from hazardous positions, activities and weight bearings. In addition, patients who are willing to use NSAIDs may be more inclined to receive joint replacement therapy [37]..."
On another note, I wouldn't count out the IL-17 blockers just because of Cosentyx. Consentyx is a weight based drug without a weight based dose. Taltz out performed in longevity, but still fails around the 3 year mark.
I agree with staying away from NSAIDs. There evidence to support (from small trials) that long term use of NSAIDs leads to faster joint replacements in people with OA. While these studies have nothing to do with PSA, but it does suggest masking the pain isn't always a good thing. I hope I don't violate the forum rules with copying a piece of that study here...
"...Our study demonstrated that compared to the non-users, NSAID users have a higher risk of knee arthoplasty. This may be because NSAIDs users had a lower perception in joint pain and disease activity, resulting in poor joint protection from hazardous positions, activities and weight bearings. In addition, patients who are willing to use NSAIDs may be more inclined to receive joint replacement therapy [37]..."