This forum active? My introduction LONG

[SquidBro]

Over here we all use different medication, some biologics, some pills, some light (very few), some creams, some alcohol (), some natural, some no treatment at all, some humour.
It really is a search what is working for you, at this moment it is not possible to define what will work for you. The project Next Generation Immuno Dermatology is going to try to make this possible, but it is a long running project.

They have found genetic elements that may make it a family-inheritance and will make you more vulnerable, but over here in this forum, we overall think that literally everyone can get it.
Triggers for getting it are widely known, things like stress are very important, trauma, streptococcus and staphylococcus, are the among the most serious.
Also smoking, alcohol, environment, BMI, etc. Are seen to have an influence.

Psoriasis of course is no skin-disease the problem is much deeper in our bodies, but exactly where….?? Well no dermatologist can tell you that.
So… most of the known medications are all suppressors of the problem. We know that the problem is in our immunesystem, so suppressing certain parts of the immunesystem (what biologics do) does work. But why the immunesystem reacts, that is not clear.
It is not an auto-immune disease as it lacks the definition of an autoimmune disease, which are antibodies… Psoriasis has no anti-bodies.

It does have comorbidities…. That is that you can get other problems, that you are more vulnarable for e.g. Crohns, or heart problems, or… well to many to want to know. Except for Psoriatic Arthritis, where you should be very alert for.
Why? Well they think that the permanent inflammation activity in our bodies can cause that.

I very much doubt that the problem is in the gut. I have never heard a dermatologist talk about a leaky gut or so, things that are popular in alternative medicine.
That the Microbiome can play a role, that is very much possible, as e.g. Alan, with his total change of diet, and more like him, do reach success.

Myself I think the problem is deep in the centre of our cells. In our cells all kinds of chemical reactions are executed and if such a reaction has a problem, it can cause waste of that faulty reaction to kick off the immune system and so cause our problems. This hypothesis has already been described, but has not yet been investigated.

Myself I am one of the DMF-gang  , as Fred always tends to say. There is enough written about it here on the board if you would do a search. It is rather common in Europe, but probably not available at your side.

As Fred says, any questions, just pose them


Caroline

Interesting that psoriasis lacks the the presence of anti-bodies as an autoimmune disease does. I did not know that. Aside from psoriasis being really annoying and an unpleasant thing to deal with, it really is a very interesting ailment.

Great overview, thank you!

I myself have pretty much come to seriously doubt that it has much to do with the gut. I still just don't know. Ive been pretty headstrong for a few years that it can be managed by natural means but im coming to seriously doubt that. I think your onto something about it being some sort of issue deep within the cells themselves.