Bimzelx for psoriatic arthritis Fred's journey

[Caroline]

It’s strange how some of the bios in pens sting and others don’t. The one I was taking last stung every time and it was a frequent jab. With Skyrizi I don’t feel it at all.
I couldn’t work out if it’s the pen itself of the liquid inside that dictates whether it hurts or not but your experience of using it both ways suggests it’s the pen thing that caused you to feel it.

Yes it has to be the pen as I got it out of the fridge for the same amount of time, the only thing I can think of with the syringe I can push it in slowly but with the pen I have no control.

I've only ever tried the pen once before many years ago with Humira, I remember that stinging and that is why I switched and always stuck to the syringe.

It seems to be related to the speed the needle is entering your skin and the sensitivity, either physical or psychological, of nerves or mind.
So if it does not hurt apparently the receiver has slow (and relaxed) nerves, that transport the pain sensation slowly or even prohibit it.  Or the receiver is an ex-marine, with the motto: “pain is an emotion, and emotions can be suppressed”

So if you do feel it… you must either have very quick and alert nerves, which transport the pain sensation very fast to your mind, where the syringe, because of the slow entry does not alert this fast mechanism. Or.. you cannot suppress your emotions, maybe you are the emotional type, when admitting to be stung by the pen and it is your sensitive mind that feels it more than a syringe.