Health Boards
Fri-24-10-2014, 16:09 PM
(Fri-24-10-2014, 10:38 AM)Fred Wrote: Though not mentioning the products by name in the study I assume it is about treating adolescent scalp psoriasis with Dovobet (Daivobet) and Dovonex (Daivonex) as it was sponsored by LEO Pharma.
Quote:
Objectives:
The primary objective was to assess the safety of once-daily application of fixed-combination calcipotriol plus betamethasone dipropionate gel in adolescent scalp psoriasis. Assessment of efficacy was a secondary objective.
Methods:
This phase II, multicentre, single-arm, open-label, 8-week trial included patients aged 12–17 years with moderate-to-very severe scalp psoriasis according to Investigator's Global Assessment (IGA) (≥ 10% of the scalp area affected).
Results:
Seventy-eight patients received treatment. Twenty-seven patients (35%) reported a total of 64 adverse events (AEs); most were mild (33/64) or moderate (22/64) in severity and there were no serious AEs. No cases of hypercalcaemia were reported, and the mean changes from baseline to end of treatment in albumin-corrected serum calcium (0·00 mmol L−1), 24-h urinary calcium excretion (−0·03 mmol per 24 h) and urinary calcium-to-creatinine ratio (−0·12 mmol g−1) were not considered clinically relevant. At the end of treatment 66 patients (85%) were clear or almost clear according to IGA. There was an 80% improvement in mean Total Sign Score from baseline to end of treatment. In total, at the end of treatment, 87% of patients rated their scalp psoriasis as clear or very mild, and 75 (96%) had no or mild pruritus compared with 14 (18%) at baseline.
Conclusions:
Once-daily calcipotriol plus betamethasone dipropionate gel is well tolerated and efficacious for scalp psoriasis in adolescents.
Source: NO LINKS ALLOWED
Dovobet And Dovonex (What's the difference ?)
It's the Dovobet gel they were testing not the Dovonex big difference but a good trial and as long as the Dovobet is used for short spells I'm sure it is fine but the trouble is if it works and the psoriasis comes back .... Which it will .... People will, as I used to go to the doctor for a repeat prescription.... So what about long term effects of steroid gels on the scalp that would be an interesting read
I know GP practices in many cases just tick a box and you can get another six repeats before renewing....... I used to do this all the time blindly applying not just the gel but the ointments all over ..... Who can blame the sufferer if the gel works for going back for more. ....it's when patients keep presenting they should call a halt and get onto something less damaging
