Health Boards
Sun-03-06-2012, 17:31 PM
Fumaric acid can bind to biochemical alcohols. The main esters which are at issue here concern dimethyl and monoethyl ester, respectively, DMF and MEF. MEF can also make compounds with metals such as K, Na, Mg, Zn, Cu, etc. Schweckendieck expanded his experiments with these esters. This was a hit. The esters worked much stronger, they could be dosed in milligrams and at high doses could even give a rise in temperature upto artificial fever.
Combination of different esters, appeared to be in practice a good choice. This led eventually to the industrial preparate Fumaderm ®, containing DMF plus various salts of MEF.
The additional commercial advantage of this complicated formula is, of course, the idea that imitation by local pharmacists of this unpatentable product, as far as possible is prevented. Fumaderm ® is extensively tested at home and abroad, including Germany and Switzerland and much used over there. Under current legislation, in the Netherlands it can only be prescribed with the aid of a so-called "Medical certificate". Because of that it is many times more expensive than psorinovo. For some years fumaderm is more or less copied and produced by Tiopharma in Oud Beijerland.
Combination of different esters, appeared to be in practice a good choice. This led eventually to the industrial preparate Fumaderm ®, containing DMF plus various salts of MEF.
The additional commercial advantage of this complicated formula is, of course, the idea that imitation by local pharmacists of this unpatentable product, as far as possible is prevented. Fumaderm ® is extensively tested at home and abroad, including Germany and Switzerland and much used over there. Under current legislation, in the Netherlands it can only be prescribed with the aid of a so-called "Medical certificate". Because of that it is many times more expensive than psorinovo. For some years fumaderm is more or less copied and produced by Tiopharma in Oud Beijerland.