Health Boards
Mon-22-12-2014, 19:16 PM
Essential differences between fumarate and the well know immuno suppressors.
Ciclosporine and other medications out of the category of immuno suppressors, which in fact have been developed for different targets, do also work in favor of psoriasis. They do this by selectively suppressing the immune system. The idea that fumarates should also be seen as an immunosuppressor, adds to the cellular vision, stated by Virchow (some guy researcher) in earlier posts mentioned studies of Kiehl and Nibbering et al. are thereby left out of consideration.
However the original author of these posts remarks that by using cyclosporine, nowhere there is a mention of "flushing" or a higher body temperature. This also holds for the newer immuno suppressors under the name of 'biological's' and recently are often used in the battle against psoriasis.
This important difference in symptoms should have been remarked by the researchers, but it seems to be overlooked by them. Perhaps because this does not fit in the paradigm of the immune-modulation. This is perhaps why the Fumarate therapy is only used by exception, which means only by psoriasis patients where no solution exists and under regular measurement of several parameters in the blood before and during the therapy. In the medical/dermatological literature there is no mentioning of measurement and comparison of body temperature before and during the treatment, mentioning the "flushing" phenomenon and/or a description of specific local skin reactions due to the fumarate treatment.
Ciclosporine and other medications out of the category of immuno suppressors, which in fact have been developed for different targets, do also work in favor of psoriasis. They do this by selectively suppressing the immune system. The idea that fumarates should also be seen as an immunosuppressor, adds to the cellular vision, stated by Virchow (some guy researcher) in earlier posts mentioned studies of Kiehl and Nibbering et al. are thereby left out of consideration.
However the original author of these posts remarks that by using cyclosporine, nowhere there is a mention of "flushing" or a higher body temperature. This also holds for the newer immuno suppressors under the name of 'biological's' and recently are often used in the battle against psoriasis.
This important difference in symptoms should have been remarked by the researchers, but it seems to be overlooked by them. Perhaps because this does not fit in the paradigm of the immune-modulation. This is perhaps why the Fumarate therapy is only used by exception, which means only by psoriasis patients where no solution exists and under regular measurement of several parameters in the blood before and during the therapy. In the medical/dermatological literature there is no mentioning of measurement and comparison of body temperature before and during the treatment, mentioning the "flushing" phenomenon and/or a description of specific local skin reactions due to the fumarate treatment.