Health Boards
Mon-22-12-2014, 20:14 PM
DMF stimulates the citric acid cycle.
In the British Journal of Clinical Pharmacology results were published by Litjens of the serum concentration of MMF after orally taking DMF with healthy volunteers. MMF appears to be only shortly detectable in the blood. The concentration in that time has a peak-formed curve.
Citate: “The present results are in agreement with our observation that dimethylfumarate is rapidly hydrolysed to monomethylfumarate at pH 8.5, but not in acidic environment ….Further hydrolysis of this metabolite to fumaric acid occurs inside cells, thus fueling their citric acid cycle, as indicated by increased CO2 concentrations in the expired air of dogs injected with fumarates”.
This research clearly shows the effect of the fumarate treatment on the citric acid cycle and therefore supports the vision that psoriasis is a mitochondrial disease. Up to now this publication has had very little attention.
Research in this direction deserves repeating and extension.
Publicized in: Litjens H N R et al. Pharmakinetics of oral fumarates in healthy subjects; B J Clin Pharm:58 issue 4, page 429 Oct 2004.
In the British Journal of Clinical Pharmacology results were published by Litjens of the serum concentration of MMF after orally taking DMF with healthy volunteers. MMF appears to be only shortly detectable in the blood. The concentration in that time has a peak-formed curve.
Citate: “The present results are in agreement with our observation that dimethylfumarate is rapidly hydrolysed to monomethylfumarate at pH 8.5, but not in acidic environment ….Further hydrolysis of this metabolite to fumaric acid occurs inside cells, thus fueling their citric acid cycle, as indicated by increased CO2 concentrations in the expired air of dogs injected with fumarates”.
This research clearly shows the effect of the fumarate treatment on the citric acid cycle and therefore supports the vision that psoriasis is a mitochondrial disease. Up to now this publication has had very little attention.
Research in this direction deserves repeating and extension.
Publicized in: Litjens H N R et al. Pharmakinetics of oral fumarates in healthy subjects; B J Clin Pharm:58 issue 4, page 429 Oct 2004.