Fumaderm advice wanted

[jiml]

I am going from the fumaderm leaflet where they give detailed levels not to go below

Can you post it? That can be valuable.

I will when I get back in I'm on the school run at the moment  

Quote:

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TRANSLATION OF THE ORIGINAL GERMAN VERSION

During the course of treatment. full blood counts (leukocyte count and differential blood count) must be monitored on a regular basis.

After starting the therapy. laboratory testing should be performed every 14 days for the first 3 months. If laboratory findings remain normal, monthly performance of blood counts is sufficient.

Blood and urinary values: To identify any possible adverse effects on liver and kidney. activity of SGOT LAST]. SGPT (ALT], gamma-GT. AP. the level of the renal function value serum creatinine of the blood. as well as urine protein and sediment should be tested prior to the start of treatment and regularly during  therapy (every 14 days during the first 4 weeks, and every 4 weeks thereafter).

Criteria for discontinuation of therapy
Leukopenia (reduction of white blood cells): Treatment with FUMADERM must be discontinued immediately in the presence of a significant reduction in leukocyte count — particularly if values are below 3,000/ul.

Lymphopenia (reduction of specific white blood cells): If the lymphocyte count drops below 500/}ul, treatment must be discontinued immediately.

If the lymphocyte count drops below 700ul, the dose must be halved. If during a follow up check after 2 — 4 weeks the absolute lymphocyte count remains below 700/ul then treatment must be discontinued. Alternative causes of lymphopenia should be excluded.

If therapy is continued in presence of severe prolonged lymphopenia, the risk of an opportunistic infection cannot be ruled out.

Other blood diseases: Treatment should be discontinued immediately and caution should be exercised if there are any other pathological changes of the blood count.

In all cases. the blood count should be monitored until normalitation Other laboratory abnormalities: Therapy must be discontinued in any case of increased creatinine levels above the normal range (see section 4).


Other medicines and FUMADERM Tell your doctor or pharmacist if you are taking. have recently taken or might take any other medicines.
The medicines listed below must not be taken at the same time as FUMADERM: During treatment with FUMADERM concomitant external use of fumaric acid derivatives. e.g. in the form of ointments and/or baths, must be avoided because additional absorption of fumaric acid by exceeding the maximal tolerable dosage. applied baths and/or ointments may lead to intoxication ma derivatives through the skin from externally Methotrexate, retinoids, psoralenes and cyclosporine must not be used concomitantly with FUMADERM. Pharmacological active ingredients which lead to suppression or reduction of the immune system reactivity (immunosuppression), medicines for cancer chemotherapy (cytostatics) and medicines with known harmful effects on the kidneys must not be administered concomitantly with FUMADERM.