Health Boards
Wed-08-05-2013, 13:36 PM
Update from Idera:
Idera Pharmaceuticals today announced presentation of data from its randomized, double-blind, placebo-controlled Phase 2 trial that showed improvements from baseline of up to 90% in Psoriasis Area Severity Index (PASI) scores in patients with moderate to severe plaque psoriasis following four weeks of treatment with the Toll-like Receptor (TLR) antagonist IMO-3100. Additionally, analysis of biopsy samples collected from patients during the Phase 2 trial indicated that PASI score improvements were associated with significant improvement of psoriasis disease-associated gene profile, including downregulation of activated genes in the IL-17 pathway, which is central to the pathogenesis of psoriasis. Treatment with IMO-3100 was well tolerated, with no treatment-related discontinuations. The presentation entitled “IMO-3100, an antagonist of Toll-like receptor (TLR) 7 and 9, demonstrates clinical activity in psoriasis patients with 4 weeks of treatment in a Phase 2a trial” was made by Alexa Kimball M.D., M.P.H., Vice Chair, Department of Dermatology at Massachusetts General Hospital, Boston, and an investigator in the trial, at the International Investigative Dermatology meeting in Edinburgh, Scotland May 8th through 13th, 2013.
“TLR antagonism provides a novel mechanism of action for the potential treatment of patients with moderate to severe plaque psoriasis. Clinical activity demonstrated in this four-week proof-of-concept trial encourages further development of TLR antagonists over longer treatment periods,” said Dr. Kimball.
“We are very pleased that the clinical improvements observed in psoriasis patients treated with IMO-3100 for four weeks correlated with the proposed mechanism of action for TLR antagonism in autoimmune diseases,” said Robert Arbeit, MD, VP of Clinical Development at Idera. “Our next step will be a 12-week Phase 2 clinical trial in patients with psoriasis, which we expect will enable us to evaluate the continued trajectory of PASI score improvement over the 12-week treatment period and maximize the clinical benefit of the treatment. We plan to conduct this 12-week Phase 2 trial with IMO-8400, an antagonist of TLRs 7, 8, and 9, and to initiate the trial during the second quarter of 2013.”
Source: iderapharma.com
Idera Pharmaceuticals today announced presentation of data from its randomized, double-blind, placebo-controlled Phase 2 trial that showed improvements from baseline of up to 90% in Psoriasis Area Severity Index (PASI) scores in patients with moderate to severe plaque psoriasis following four weeks of treatment with the Toll-like Receptor (TLR) antagonist IMO-3100. Additionally, analysis of biopsy samples collected from patients during the Phase 2 trial indicated that PASI score improvements were associated with significant improvement of psoriasis disease-associated gene profile, including downregulation of activated genes in the IL-17 pathway, which is central to the pathogenesis of psoriasis. Treatment with IMO-3100 was well tolerated, with no treatment-related discontinuations. The presentation entitled “IMO-3100, an antagonist of Toll-like receptor (TLR) 7 and 9, demonstrates clinical activity in psoriasis patients with 4 weeks of treatment in a Phase 2a trial” was made by Alexa Kimball M.D., M.P.H., Vice Chair, Department of Dermatology at Massachusetts General Hospital, Boston, and an investigator in the trial, at the International Investigative Dermatology meeting in Edinburgh, Scotland May 8th through 13th, 2013.
“TLR antagonism provides a novel mechanism of action for the potential treatment of patients with moderate to severe plaque psoriasis. Clinical activity demonstrated in this four-week proof-of-concept trial encourages further development of TLR antagonists over longer treatment periods,” said Dr. Kimball.
“We are very pleased that the clinical improvements observed in psoriasis patients treated with IMO-3100 for four weeks correlated with the proposed mechanism of action for TLR antagonism in autoimmune diseases,” said Robert Arbeit, MD, VP of Clinical Development at Idera. “Our next step will be a 12-week Phase 2 clinical trial in patients with psoriasis, which we expect will enable us to evaluate the continued trajectory of PASI score improvement over the 12-week treatment period and maximize the clinical benefit of the treatment. We plan to conduct this 12-week Phase 2 trial with IMO-8400, an antagonist of TLRs 7, 8, and 9, and to initiate the trial during the second quarter of 2013.”
Source: iderapharma.com
