[split] Dimethylfumarates and Psoriasis

[Caroline]

Caroline, there is research that shows reduced drug efficacy in patients who have developed antibodies for the particular drug. Search "antidrug antibody psoriasis". DMF is probably way too small and breaks down way too fast for such a problem. Once started on DMF, if you can get efficacy without destroying your lymphocytes you can keep going. I apologise for being brief, but generally I dont like rambling on: I would rather be playing with my dogs.

Cheers,

Bill

Indeed Bill, DMF seems to be in a special position. Still there are mentions of people with whom also the DMF started to fail. Also my doc said to me that it is possible that you body will also finally resist against DMF. He therefore advises the intermittent approach that you are following and he suggests that you sometimes should take a break of a few months and then restart again.

On the one side I know a few people where the DMF stopped working or who needed to have a higher dose, on the other hand I know people who have used it for ten's of years and with whom it it still working excellently.

Cheers,
Caroline.