Skilarence [Duncan's thread]

[Duncan]

Looks like another drug failed due to diarrhoea.
 I tried Oteza. It was working but the longer I was on it, the worse my diarrhoea got.
I am now on Skilerence. Only got to 2x 120mg tablets a day. No will I get to 6 a day. Horrendous stomach pains at times, but the diarrhoea is now bad

Very limited what I can take due to high blood pressure

[Fred]

Good luck Duncan, I think the DMF gang may be able to advise about the stomach pains and I'm sure the will spot this thread.

I made an edit to your thread subject as we have this one for information. Skilarence

You may also want to change the treatment in your profile as it says "enstilar diprosalic dovobet"

Fred.

[Caroline]

Hi Duncan,

Yes that is a known problem with DMF for already 35, years. Almirall made the wrong medicine, they should have made a slow release version.
It is obvious that something that is hurting your intestines, will hurt much less if you spread this over time, so slow or controlled release.  This obviousness, which is incredible logical for any sensible patient, is not part of the thinking world of the experts that make this medication.

In the Netherlands we have, again since 35 years, a slow release version because there was one doctor and one pharmacist who had their brain clear.
This version is still made in a magistrate way. You might think, because of that, that someone makes it by hand so quality is not controlled, but that is not true. It is a controlled produced by a machine. (I have seen it).

It probably will not be covered by your insurance, but you could speak with them. It can be ordered by mail and is twice as cheap as what you have now.
I personally use it with marginal intestine problems.
In the Netherlands it can be prescibed as there is no other medication with this characteristics. While the working substance is still the same. Even the advantage is that max prescription can go highe than 6x120 and signals from patients are that a lot of them need 8x120 to have it started really good.

In order to reduce the intestine pains, they are NOT stomach pains, you should only take the pills during your largest meal, perhaps by the end of the meal and fill up your dessert yoghurt alike.

Caroline
Member of the DMF gang.

[jiml]

Looks like another drug failed due to diarrhoea.
 I tried Oteza. It was working but the longer I was on it, the worse my diarrhoea got.
I am now on Skilerence. Only got to 2x 120mg tablets a day. No will I get to 6 a day. Horrendous stomach pains at times, but the diarrhoea is now bad

Very limited what I can take due to high blood pressure

Hi Duncan sorry the Skilarence is giving you the cramps and worse still the diarrhoea if it has only got like this since upping the dose. If it has just begun I would say drop back a tablet and see how it goes it might be your body resisting the increase
To minimise the cramps and maybe the diarrhoea make sure you drink plenty and  take with food.
And as Caroline suggests take them with yoghurt

[Duncan]

Looks like another drug failed due to diarrhoea.
 I tried Oteza. It was working but the longer I was on it, the worse my diarrhoea got.
I am now on Skilerence. Only got to 2x 120mg tablets a day. No will I get to 6 a day. Horrendous stomach pains at times, but the diarrhoea is now bad

Very limited what I can take due to high blood pressure

Hi Duncan sorry the Skilarence is giving you the cramps and worse still the diarrhoea if it has only got like this since upping the dose. If it has just begun I would say drop back a tablet and see how it goes it might be your body resisting the increase
To minimise the cramps and maybe the diarrhoea make sure you drink plenty and  take with food.
And as Caroline suggests take them with yoghurt

Its difficult to take them with a meal 3 times a day.
It says to increase the dosage every week. Ill stay on the 2 a day and see if my body gets used to them.
Cramps arnt the main problem. I have found drinking when they come on relieves it. Its the diarrhoea. Scared to go out of the house for long.
Ill see how it goes

[Duncan]

Hi Duncan,

Yes that is a known problem with DMF for already 35, years. Almirall made the wrong medicine, they should have made a slow release version.
It is obvious that something that is hurting your intestines, will hurt much less if you spread this over time, so slow or controlled release.  This obviousness, which is incredible logical for any sensible patient, is not part of the thinking world of the experts that make this medication.

In the Netherlands we have, again since 35 years, a slow release version because there was one doctor and one pharmacist who had their brain clear.
This version is still made in a magistrate way. You might think, because of that, that someone makes it by hand so quality is not controlled, but that is not true. It is a controlled produced by a machine. (I have seen it).

It probably will not be covered by your insurance, but you could speak with them. It can be ordered by mail and is twice as cheap as what you have now.
I personally use it with marginal intestine problems.
In the Netherlands it can be prescibed as there is no other medication with this characteristics. While the working substance is still the same. Even the advantage is that max prescription can go highe than 6x120 and signals from patients are that a lot of them need 8x120 to have it started really good.

In order to reduce the intestine pains, they are NOT stomach pains, you should only take  the pills during your largest meal, perhaps by the end of the meal and fill up your dessert yoghurt alike.

Caroline
Member of the DMF gang.
Hi Caroline.
I am in the UK. We don't have insurance. Its free.
I am not sure if slow release is an option. I shall ask 

[Duncan]

Good luck Duncan, I think the DMF gang may be able to advise about the stomach pains and I'm sure the will spot this thread.

I made an edit to your thread subject as we have this one for information. Skilarence

You may also want to change the treatment in your profile as it says "enstilar diprosalic dovobet"

Fred.
Hi Fred. Ii am still on "Enstilar and Diprosalic" when I find an oral treatment that works, ill change it

[jiml]

Hi Duncan,

Yes that is a known problem with DMF for already 35, years. Almirall made the wrong medicine, they should have made a slow release version.
It is obvious that something that is hurting your intestines, will hurt much less if you spread this over time, so slow or controlled release.  This obviousness, which is incredible logical for any sensible patient, is not part of the thinking world of the experts that make this medication.

In the Netherlands we have, again since 35 years, a slow release version because there was one doctor and one pharmacist who had their brain clear.
This version is still made in a magistrate way. You might think, because of that, that someone makes it by hand so quality is not controlled, but that is not true. It is a controlled produced by a machine. (I have seen it).

It probably will not be covered by your insurance, but you could speak with them. It can be ordered by mail and is twice as cheap as what you have now.
I personally use it with marginal intestine problems.
In the Netherlands it can be prescibed as there is no other medication with this characteristics. While the working substance is still the same. Even the advantage is that max prescription can go highe than 6x120 and signals from patients are that a lot of them need 8x120 to have it started really good.

In order to reduce the intestine pains, they are NOT stomach pains, you should only take  the pills during your largest meal, perhaps by the end of the meal and fill up your dessert yoghurt alike.

Caroline
Member of the DMF gang.
Hi Caroline.
I am in the UK. We don't have insurance. Its free.
I am not sure if slow release is an option. I shall ask 

No Duncan the slow release one Caroline mentions is not available in the UK
So I'm afraid you will have to manage on Skilarence
If the diarrhoea persists you might have to stop or stay on the lower dose till it's no longer a problem

[sunnyman]

Hi Duncan !

Good luck and let's hope that you will feel well without side effects.
Now , i'm on the week 7 and i never had intestinal problems , no diarrhea.
Rare episode of flushing.
My skyn is not bad , the improvement is slower than i expected.
This therapy should be done without stress.

Fingers crossed !!!

[Bill]

Hello Duncan,

I cannot add much to the helpful comments proffered. Keeping well hydrated and taking your medication with a good meal, preferably with plenty of dairy, is the way to go. I found that pre-dosing with N-acetyl l-cysteine reduced the side effects, but as I now take half the DMF dose on its own with good effect I don't bother with anything. I am over six and a half years on the raw chemical with excellent and ongoing results.

I hope things settle for you soon.

Cheers