Interesting snippet about Humira

[Turnedlight]

I began using Humira in 2007 and achieved a remission in long-standing, severe Crohn's.  In January 2021 (I moved to a new location), my new GI doctor sent a prescription for the Citrate Free Humira.  I noticed increased mild nausea feelings and increased skin eruption.  I had a small rash on my lower leg that came and went since 2012 when I took up roller skating again (the sport and love of my youth).  The dermatologist I saw, then, said the rash was due to stasis dermatitis and recommended compression stockings.  The rash continued coming and going but remained small and uneventful.

Suddenly, this year in conjunction with the different Humira formula, the rash grew and became raised and painful, prompting care with a different dermatologist, since I had moved.  Frustration over thinning skin, bleeding, and increased eruptions of rash led me to this forum and to understanding that the topical steroid ointments may have worsened the condition and that there are other treatments out there..

I have wondered if the change in Humira may have triggered some different response in my immune system.  In July, I went back to the original formula for Humira but have noticed no improvement, skinwise.  

A friend of mine who had a glioblastoma brain tumor was holding his own for a long while until his doctor fiddled with the dosage of one of his main medications to treat the cancer, lowering the dosage since he was doing well.  At that point, his cancer accelerated quickly and took him.  Perhaps it was coincidental, but it didn't seem that way.  I wonder if you get a medicine that is working for you, whatever it is, maybe it's not wise to change it.  Maybe the change in the Humira led to the aggravation of the drug induced psoriasis.

Alternatively, you just don’t get on with whatever new ingredient is replacing the citrate?
I agree though, it’s often when there’s even a small change that things go wrong.
I’ve also been through a number of bios because they didn’t work, or only work for a limited period of time, usually about a year. Stelara was fab, then it stopped working. Humira never did anything for me, just didn’t work at all. I think the same happened with Taltz.

[Caroline]

The saying: “Don’t fix what is not broken” , may be very relevant over here. Why change, if things are working well… I don’t get that.

It is thinkable that Humira was good working for both Crohns and psoriasis. The change apparantly spoiled this.
If you read the forum extensively, but that is a hell of a job, then you will see that Humira, just like many other medications/biologics, at a certain point loses its working. The reason for that is that in the end the body/immune system starts to make anti-bodies against it. After which it loses effectivity and you have to switch to a different bio, of which there are more an more.
There are already combination therapies where Biologicals and an immunosuppressor, mostly mtx, are used with the goal to prevent the body to make anti-bodies.

Hope that in your case, they can find some that works for both Crohns and psoriasis