Knee pain and psoriatic arthritis

[Fred]

Could knee arthralgia and cartilage thinning in psoriasis patients be clues to early psoriatic arthritis ?

Quote:

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Background:
To compare femoral cartilage thickness between patients with psoriasis (PsO) and psoriatic arthritis (PsA), and to investigate whether knee joint pain in PsO patients could be an early risk factor for PsA.

Methods:
Fifty-nine patients (28 PsO and 31 PsA) were included in this cross-sectional study. Demographic data were collected, and clinical assessments were performed using the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score 28 (DAS28). PsO patients were evaluated for knee arthralgia symptoms within the past month. Femoral cartilage thickness was measured bilaterally at the medial femoral condyle, lateral femoral condyle, and intercondylar area using ultrasonography.

Results:
Femoral cartilage thickness was significantly lower in PsA patients compared to those with PsO (p < 0.05). Among patients with PsO, those reporting arthralgia (n = 14) had significantly reduced lateral femoral condyle cartilage thickness in both knees compared to those without arthralgia (p < 0.05). Spearman correlation analysis revealed a negative correlation between age and lateral cartilage thickness (e.g., right LFC: ρ = −0.338, p = 0.009, 95% CI –0.55 to −0.09). PASI scores showed a consistent positive correlation with femoral cartilage thickness across regions; for example, the correlation with the left LFC was significant (ρ = 0.504, p < 0.01, 95% CI 0.29–0.67). These associations indicate that both demographic and disease-related factors may influence cartilage status in PsO and PsA, although the confidence intervals indicate some degree of uncertainty and call for validation in larger cohorts.

Conclusions:
Femoral cartilage thinning is evident in PsA patients and may begin even in the subclinical phase. In PsO patients, the presence of arthralgia, especially in the lateral femoral condyle, may reflect early structural changes and could serve as a predictor for PsA development. Ultrasonographic assessment offers a noninvasive, accessible method for early detection and follow-up.

Source: onlinelibrary.wiley.com

*Funding: Malatya İnönü University

[Caroline]

It is interesting there seems to be a correlation.

Though I have never heard of it from anyone

And with me that was not at all how it started, the indications with me were the tendons… and that is what I have heard much more often.
No problem with the knees.

[Fred]

My first sign was in one of my thumb knuckles

[glenda grant]

hi Fred,
Haven't BEEN AROUND JUST SO MUCH GOING ON IN MY LIFE. MY PSORIASIS IS GOOD NONE ON MY SKIN BUT THE PSORIATIC ARTHRITIS IS KILLING ME WITH EXTREME PAIN IN MY KNEES THEY WANT ME TO GET NEW KNEES PUT IN BUT I AM NOT READY FOR THAT JUST YET I AM BABYING THEM. I HAVE DIABETES BUT ITS UNDER CONTROL BUT I HAVE NEUROPATHY MY FEET ARE NUMB ALL THE WAY UP TO MY KNEES,I CAN BARELY SLEEP DUE TO THE PAIN.I TAKE TRAMADOL 50 MG AT BEDTIME AND SOMETIMES TRAZADONE 50 MG WHEN I AM HURTING BAD LIKE TONIGHT.I GET SHOTS IN MY KNEES BUT DIDN'T GET ONE 3 MONTHS AGO WHICH I SHOULD HAVE.I GO SEE MY RHEUMATOLOGIST IN JAN I WILL GET THE SHOT STEROID IT HELPS FOR 6 WEEKS OR SO. DOES ANYONE ELSE HAVE ANYTHING SIMULAR. NIGHTS ARE HORRIBLE I TOSS AND TURN ALL NIGHT JUST CAN'T GET RESTED.HOPE ALL IS WELL WITH YOU FRED AND THE GROUP.I WILL BE ON MORE FREQUENTLY. yours truly GLENDA

[glenda grant]

forgot to say i am on skyrizi injection every 90 days