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Psoriasis Club › HealthHealth Boards › Prescribed Treatments For Psoriasis v
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worse on biologics

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worse on biologics
awesomeman Offline
Member


Posts: 23
Threads: 5
Joined: Oct 2017
Gender: Male
Location: florida
Treatment: Cosentyx
#1
Wed-21-03-2018, 13:56 PM
Has anyone here gotten worse on biologics?  I just started cimzia about a month ago and I feel like things are getting worse.  Is this common?
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Evan Offline
Novice


Posts: 7
Threads: 1
Joined: Nov 2017
Gender: Male
Location: California
Treatment: Siliq biologic, steroids
#2
Wed-21-03-2018, 14:09 PM
It shouldn't.  I've been on Siliq since last summer, 100% clear skin since then (for first time in my life).  I don't see any reduction in effectiveness since I've been using it, and for sure I haven't felt any depression (I think that's totally b.s. based on my first hand experience) very happy so far with the results.

Up to you and your doctor but maybe you should give Siliq a try, it's supposed to be the lowest priced of all the biologics out there, despite being the most effective, go figure...gl
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awesomeman Offline Author
Member


Posts: 23
Threads: 5
Joined: Oct 2017
Gender: Male
Location: florida
Treatment: Cosentyx
#3
Wed-21-03-2018, 14:16 PM
Ive tried a lot of different things and this has happened on other meds.  Just frustrated and curious why this may be happening.
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Fred Offline
I Wanted To Change the World But Got Up Far Too Late.
Moderator
Posts: 67,201
Threads: 3,902
Joined: Aug 2011
Gender: Male
Location: France
Psoriatic Arthritis Score: 1
PQOLS: 1
Treatment: Bimzelx / Coconut Oil
#4
Wed-21-03-2018, 17:14 PM
What do you mean by worse ?

If you mean the psoriasis has getting worse, then no it only ever got better for me.

If you mean health wise in another way. I did have a bad reaction to Remicade and Humira.
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mataribot Offline
100 + Member I Just Cant Stop !

100 + Member I Just Cant Stop !
Posts: 1,340
Threads: 38
Joined: Jun 2013
Gender: Male
Location: USA
Treatment: >_<
#5
Wed-21-03-2018, 17:20 PM
Not uncommon for this to occur with TNFs... have tried Stelara?
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awesomeman Offline Author
Member


Posts: 23
Threads: 5
Joined: Oct 2017
Gender: Male
Location: florida
Treatment: Cosentyx
#6
Wed-21-03-2018, 17:26 PM
(Wed-21-03-2018, 17:20 PM)mataribot Wrote: Not uncommon for this to occur with TNFs... have tried Stelara?

So its not uncommon.  Im more arthritis and yes the athritis is flaired up quite a bit since starting the cimzia.  Is there any literature I can read or learn why this happens.
Thanks
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Fred Offline
I Wanted To Change the World But Got Up Far Too Late.
Moderator
Posts: 67,201
Threads: 3,902
Joined: Aug 2011
Gender: Male
Location: France
Psoriatic Arthritis Score: 1
PQOLS: 1
Treatment: Bimzelx / Coconut Oil
#7
Wed-21-03-2018, 17:31 PM
(Wed-21-03-2018, 17:26 PM)awesomeman Wrote:
(Wed-21-03-2018, 17:20 PM)mataribot Wrote: Not uncommon for this to occur with TNFs... have tried Stelara?

So its not uncommon.  Im more arthritis and yes the athritis is flaired up quite a bit since starting the cimzia.  Is there any literature I can read or learn why this happens.
Thanks

You could try the Search you will find all studies there.
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Turnedlight Offline
100 + Member I Just Cant Stop !

100 + Member I Just Cant Stop !
Posts: 6,178
Threads: 62
Joined: Apr 2015
Gender: Female
Location: Uk
Treatment: Skyrizi
#8
Wed-21-03-2018, 18:04 PM
I have had biologics not work at all, and another work very well. I guess they don’t all work for everyone..
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awesomeman Offline Author
Member


Posts: 23
Threads: 5
Joined: Oct 2017
Gender: Male
Location: florida
Treatment: Cosentyx
#9
Wed-21-03-2018, 18:11 PM
Yeah I know many have tried with not working.  Im just trying to find some literature or something that describes why it may get worse and to see if its common or not.
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mataribot Offline
100 + Member I Just Cant Stop !

100 + Member I Just Cant Stop !
Posts: 1,340
Threads: 38
Joined: Jun 2013
Gender: Male
Location: USA
Treatment: >_<
#10
Wed-21-03-2018, 19:04 PM
The number is around 10% that Psoriasis does not get better or flares up. As for the research, it’s listed in phase III trials for each of the manufacturer.

There two things you can try - add nother drug such as MTX, or switch to another bio that isn’t a TNF.
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