Hello, 50+ LDN user

[Bill]

I am glad that you are finding answers. Now that you have found them you have to ask yourself, "Were they the right answers?" and "Are the questions still the same?". Illness, like everything else in life, is not static, and there is no point in pointless ritual. Maybe in past times people with serious illness died, so things may be better now.

Keep looking!

[Closed]

"Maybe in past times people with serious illness died, so things may be better now."

Granted, everything is relative. We live longer now, so diseases would be more prevalent as our age expectancy increases. I understand that.

Knowledge and science has it benefits.

There are many times we find answers or find discoveries. Yet still don't know how they came to be. So the questions always change. As long as our thirst for knowledge doesn't diminish,  we are on the right track.

For example,... the latest study on LDN 6/16, found that LDN upregulates a unique set of gene expressions not seen with normal doses. LDN had a selective impact on genes involved with cell cycle regulation and immune modulation.

Our thirst for knowledge should always continue.

[Closed]

"The latest study on LDN 6/16, found that LDN upregulates a unique set of gene expressions not seen with normal doses. LDN had a selective impact on genes involved with cell cycle regulation and immune modulation."

The reason I make mention of this study besides a thirst for knowledge and its recent publication is,... how it might have implications for us psoriasis patients.

This study was observed on cancer cell lines. But if it showed an upregulation of genes involved with cell cycle regulation and immune modulation, you could see how this would benefit psoriasis also.

Psoriasis is an unregulated growth of skin cells. Producing skin cells in a day that would normally take a month or there abouts. So cell cycle regulation, (which is the process of proliferation and growth of cells), being modified through gene expression, might have a major impact in those with psoriasis. Not to mention LDN's effects on genes, involved with immune modulation. Possibly correcting or modulating a dysfunctional immune response as in autoimmunity.

So here we have two distinct pathways in which LDN might possibly benefit those with psoriasis as well as with cancer.

My mind continues to think things through. 

[Bill]

It may work. It may not. It depends on whether the effect outweighs the disease causing processes. That is why the "Suck it and see." approach is so important. I had a marked improvement with DMF within six weeks. The result was not as I had imagined. No amount of reading and theorising could have given me the insight I have gained from taking the drug. Theory and practice are dancing partners, not competing rappers. You should keep in step.

[Closed]

"It depends on whether the effect outweighs the disease causing processes."

And also how far along these processes are. How long they have been in use. That's why I made a point of telling the story, how doctors had better results with the more recently diagnosed, than with people who had been suffering for 20 years.

"It may work. It may not."

Most of what I got from that study, is my take on the possibilities how it might pertain to us, those with psoriasis and PsA. Just possibilities, like it may or may not.

And since there is no down side to taking LDN, I think it makes sense to explore those possibilities.

"Theory and practice are dancing partners, not competing rappers. You should keep in step."

Yes, while it is only my theory on how the benefits of LDN in this particular study,  might be helpful to those with psoriasis, let's not forget it has already done so for many individuals.

In reading many testimonials from LDN users, most of whom take it for more life threatening conditions like cancer, MS, AIDS, and the like, some matter of factly say, oh it seems to have cleared my psoriasis too. These are the kind of testimonials that are worth their weight in gold. Because they are given freely as a second thought. A not looked for result, just an added bonus.

My testimony, when I'm ready to give it months from now, won't hold water against those because I'm looking for a primary effect.

[Bill]

What parameters have you set for your ldn? Conservatively, I would want at least 75% of the disease gone within three months. Although you think there is no downside, you dont want to be distracting yourself from other candidates. Doggedly sticking with something that isnt working is harmful. You need to have alternatives; Hopefully you wont need them.

Cheers,

Bill

[Closed]

"What parameters have you set for your ldn? Conservatively, I would want at least 75% of the disease gone within three months. Although you think there is no downside, you dont want to be distracting yourself from other candidates. Doggedly sticking with something that isnt working is harmful. You need to have alternatives;"

This is a good question Bill, if it wasn't already answered before. I suggest maybe reading the thread over again or better yet researching LDN on your own.

You need at least 6 months to give this a thorough test. Results might come sooner, but you need to give it time. Remember, this is not a drug that is suppressing symptoms. It is correcting the causes of those symptoms. In effect, regulating futher damage, and allowing your body to heal itself. None of the other candidates, work this way. This drug in low dose form, works much like a nutritional supplement, in that it assists in helping the body to function optimally. And much like nutrients, if you stop taking them, then you body doesn't work as well. So LDN needs to be continued. But that is a good thing, because it benefits the entire body, unlike most drugs that are harmful with long-term use.

I believe I mentioned all of this earlier.

Alternatives are always available if needed. Infact, they might be able to work together with LDN. But it is recommended to give LDN, at least 6 months to fully show benefits. And that is not unreasonable, in that you are treating the diseased state with your body's natural ability to heal and improve itself.

I think the reason for the confusion you might have is because I did not explain the mechanisms of LDN in the body. At a low dose, in which these benefits could only be achieved,  LDN blocks the endorphin receptors for a short time, thereby signaling the brain to release more endorphins. It believes there is a shortage, so it releases more. It's been shown in studies to increase endorphin levels 3 fold. Now being the Naltrexone is of a low dose, it leaves the body in 3 to 4 hours, leaving this 3 fold increase in endorphins to connect to their receptors. These receptors are found on all the cells of our body. These particular receptors in which the endorphins connect to, control and regulate cell cycle growth and proliferation. Endorphins have a long half life (20 hrs). So if you take LDN once nightly, it leaves the body in a few hours, leaving your endorphins tripled to connect to receptors all throughout the next day.

If you would like to know more, I suggest you type in endorphins at REMOVED and see what they can do.

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Edit by Fred: Reference to website removed.

[Fred]

Just to remind you, Psoriasis Club does not allow the promotion of other websites. I have removed the reference you posted, please keep to our rules.

Thank you.

Fred.

[Closed]

Even government websites?

[Fred]

Even government websites?

I have just answered your PM.

But just to clarify: Psoriasis Club does not allow it's members to promote other websites. We are totally independent as I have said to you before and a line has to be drawn somewhere. We know it's not a popular decision to everyone but our active members like things the way they are.

Psoriasis Club is not a place for people to promote other website be they government or miracle cures. It's a place different from other psoriasis websites in that we are independent.

I can tell by conversations I have had with you that you are not happy with our decision, but it's the way we like it.

Fred.    

EDIT: I've just read your other PM. And yes I do publish studies and news articles from reliable sources and I work very hard to make sure it is indeed reliable information. It's important to me to make sure that our readers are getting the correct information and a lot of work goes in to making sure it is reliable. That doesn't mean no other information is not valid, but we do protect our members and readers from false information and that is why we don't allow members to promote other websites.

Should you feel there is news or studies that we may have missed about the treatment of psoriasis then by all means run it past me and I will get our team to look into it.