Hello from Janet

[jiml]

Hi again  I think I am right in saying the FAEs are not damaging to kidneys if monitored closely
So my treatment may be worth mentioning to your dermatologist and renal specialist.....

I did find this in the literature

Quote:

---

Haematological changes, notably leucopenia, lymphopenia and eosinophilia, are frequently observed during FAE therapy.[74,75] These changes are generally reversible following discontinuation of treatment, and to date there has been no evidence of an increased risk of infection.[74,75] Additional laboratory changes noted during FAE therapy include increases in liver enzymes, cholesterol, triglycerides, serum potassium and serum creatinine, and proteinuria.[74,75]

There were several early reports of acute renal failure associated with uncontrolled, concomitant use of oral and topical fumaric acid derivatives,[78,84,85] and a case of chronic renal damage after long-term, high-dose oral FAE therapy.[86] Current guidelines recommend a gradual increase in oral FAE dose to determine each patient's maximum tolerable dose, and advise against concomitant use of topical fumaric acid derivatives to avoid exceeding the maximum dose through percutaneous absorption.[74,75] When used according to these guidelines in controlled clinical trials, no nephrotoxicity has been observed.[74,87] Nevertheless, sufficient fluid intake should be encouraged during FAE therapy,[75,82] and renal function should be monitored throughout treatment.

Source medscape.com