Health Boards
Sun-01-09-2013, 11:56 AM
Before saying it's a nail in the coffin for MTX you really need to look at the immunological consequences of the other biological drugs available to treat PsA and deal with the patient responses regarding their success in treatment with the drug.
Personally I am loving it... I have next to no immunocompromisation and have not had a single issue with my PsA since starting on 10mg/week of MTX over a year ago.
Sure the potential side effects can be bad, but so can the side effects of many medications (paracetamol can cause liver damage) which can be bought over the counter.
I'll have a read through some of the research papers on the different biologicals and put together an "effects on the immune system and biochemistry" article and attempt to explain the side effects and pathways altered by the different drugs...
Personally, I believe anything that changes your biochemical processes leaving you potentially immunocompromised is never a great thing, but since PsA and PsO are immune diseases there is very little choice but to do this.
Krissie
Personally I am loving it... I have next to no immunocompromisation and have not had a single issue with my PsA since starting on 10mg/week of MTX over a year ago.
Sure the potential side effects can be bad, but so can the side effects of many medications (paracetamol can cause liver damage) which can be bought over the counter.
I'll have a read through some of the research papers on the different biologicals and put together an "effects on the immune system and biochemistry" article and attempt to explain the side effects and pathways altered by the different drugs...
Personally, I believe anything that changes your biochemical processes leaving you potentially immunocompromised is never a great thing, but since PsA and PsO are immune diseases there is very little choice but to do this.
Krissie