Psoriatic arthritis is getting undiagnosed

[Fred]

I have read where the gene marker for PSA has been Identified. Scientists have found a PSA gene marker on what is called a locus. A specific place on a chromosome where genetic variations happen. Scientisits have found a genetic variation or gene marker for psoriatic arthritis on a locus on chromosome 5. Scientists found this marker to make a patient prone to PSA and not Psoriasis. Now it's narrowed down to the IL-23 monoclonal antibody drug is the next step for research for PsA.

Merck highlites R&D of anti-interleukin-23

Also another med for Psoriasis has been approved in the U.S. IL-17a interleukin pathway 17-A
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody for P. & PSA. Hope it's available for you. I read it can clear P. Patients with 40%-60% coverage in 3-4 weeks.

Yes we have a lot of information on Cosentyx and it's in our list of Biological Treatments For Psoriasis

As for trials I nearly went on the ASP015K one, but didn't get it because I had been using Bio's for to long. But trials are not something I would normaly go for, and if I did it would be through my hospital.

Hi  
Have you tried cosentyx?

Hello Quest, no I haven't tried Cosentyx as it's not yet available to me. It may be available next year sometime but I'm not sure when.

[Quest4Cure]

I have read where the gene marker for PSA has been Identified. Scientists have found a PSA gene marker on what is called a locus. A specific place on a chromosome where genetic variations happen. Scientisits have found a genetic variation or gene marker for psoriatic arthritis on a locus on chromosome 5. Scientists found this marker to make a patient prone to PSA and not Psoriasis. Now it's narrowed down to the IL-23 monoclonal antibody drug is the next step for research for PsA.

Merck highlites R&D of anti-interleukin-23

Also another med for Psoriasis has been approved in the U.S. IL-17a interleukin pathway 17-A
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody for P. & PSA. Hope it's available for you. I read it can clear P. Patients with 40%-60% coverage in 3-4 weeks.

Yes we have a lot of information on Cosentyx and it's in our list of Biological Treatments For Psoriasis

As for trials I nearly went on the ASP015K one, but didn't get it because I had been using Bio's for to long. But trials are not something I would normaly go for, and if I did it would be through my hospital.

Hi  
Have you tried cosentyx?

Hello Quest, no I haven't tried Cosentyx as it's not yet available to me. It may be available next year sometime but I'm not sure when.

Hi Fred,  
I hope it can be availble to you soon it sounds promising with less side effects.

[Fred]

Hi Fred,  
I hope it can be availble to you soon it sounds promising with less side effects.

Yes it is showing good results, but this is France and nothing happens quickly here.

[Quest4Cure]

Hi Fred,  
I hope it can be availble to you soon it sounds promising with less side effects.

Yes it is showing good results, but this is France and nothing happens quickly here.  

Hi Fred,
So sorry things move so slowly in France.
Only psoriasis moves quicker than the drugs designed to put P. in remission or to be approved or prescribed. To many hoops to jump thru for those like yourself who need the drug "now" . It was approved in Jan 2015 in Europe. New drugs have web sites to help with dr prescribing in your area and a pmt plans if needed and if you fill the drug companies requirements.

Some of the bio drugs as are bogged down by insurance companies preapproval. Several other drugs required to be tried first. Corse I dint know what bios you have tried.
Then again immunsuppression drugs are not always for everyone due to the many risks/prerequisites .
Hope you feel well soon!    

[Fred]

Hi Fred,
So sorry things move so slowly in France.
Only psoriasis moves quicker than the drugs designed to put P. in remission or to be approved or prescribed. To many hoops to jump thru for those like yourself who need the drug "now" . It was approved in Jan 2015 in Europe. New drugs have web sites to help with dr prescribing in your area and a pmt plans if needed and if you fill the drug companies requirements.

Some of the bio drugs as are bogged down by insurance companies preapproval. Several other drugs required to be tried first. Corse I dint know what bios you have tried.
Then again immunsuppression drugs are not always for everyone due to the many risks/prerequisites .
Hope you feel well soon!    

Oh I like it slow, that's why I live here.  

Yes it was January Cosentyx approved for treating psoriasis in Europe But the individual countries still decide when they will start using it, just because it's got approval doesn't mean it will get used either. Otezla for example is available to patients in Scotland for psoriatic arthritis, but it's not going to be made available to those in England and Wales.

Also we don't have the same system as you and there is no point in us asking the drug companies, they can't help and they don't offer help with payments as we don't need them.

If France decide to use it I may be given the chance, (there is talk it could be available next year) but I just have to wait and see what they decide. They started trialling Fumaderm, but stopped so there is never any guarantee that France will get the same medication as the USA or the rest of Europe come to that.

Quest I think we should stop the conversation about Cosentyx here as we are derailing this thread and going a bit  

Regards.

Fred.

[Quest4Cure]

But is it true that there is a vast amount of PsA after psoriasis?
That is a no isn't it?
Isn't it about max 20% or even less who get PSA ?

Still think it is smart of The derms to check for it. But.... It is not their thing, as they watch the skin, not the joints. They are limited by profession.

Well according to our own latest research in this page: https://psoriasisclub.org/whatispsoriasis.php Psoriasis affects around 1 in 50 people worldwide and around 20% of those will go on to have psoriatic arthritis.

So yes you are right it is low, but as an psoriatic arthritis person myself I wish it had been diagnosed earlier. And yes you are right a dermatologist is more interested in the skin, but here at least they are trialling joint consultations with a dermatologist and a rheumatologist at the same time. I have had one and it's been successfull, I have another in a months time and I must say it's a good step forward but I don't know if other countries are trying this.

It was not done when I went to the hospital, the rheumatologist knew what he was talking about, but had no clue of what to do next except for MTX.
Had to find out everything myself.  

My rheumy explained that Psoriatic arthritis is a type of inflammation that occurs in about 15% of patients who have psoriasis. This particular arthritis can affect any joint in the body, and symptoms vary from person to person. Some stages are finger nails lifting from the nail beds are obvious tale tale signs of this disease in hands fingers & toes, & sausage fingers and toes. I have two bionic hips from PSA.

[Turnedlight]

I have a feeling that my derm department had no interest in diagnosing psa because I was going on mtx which is what they would give me anyway.
However they did diagnose it 'clinically' by my collection of symptoms.

Had they asked 'do you have joint pain' I would have said no. That isn't how my psa has manifested itself, it's all tendon related in my feet and ankles, and the carpal tunnel in the wrist so far. So perhaps I'm in early stages of psa and they aren't bothered as long as they are prescribing drugs for my skin which also work for elsewhere.

I have been told twice (by my GP) I'll see a rheumy but I never have, and begin to suspect that I won't unless symptoms get worse. I have seen podiatrists though.

[jiml]

I have a feeling that my derm department had no interest in diagnosing psa because I was going on mtx which is what they would give me anyway.
However they did diagnose it 'clinically' by my collection of symptoms.

Had they asked 'do you have joint pain' I would have said no. That isn't how my psa has manifested itself, it's all tendon related in my feet and ankles, and the carpal tunnel in the wrist so far. So perhaps I'm in early stages of psa and they aren't bothered as long as they are prescribing drugs for my skin which also work for elsewhere.

I have been told twice (by my GP) I'll see a rheumy but I never have, and begin to suspect that I won't unless symptoms get worse. I have seen podiatrists though.

Yes I'm the same they ask in passing about joint pain and are quick not to ask to much
I'm fortunate so far as my psoriasis has been mainly skin but I suspect I'm experiencing changes in my foot joints when I get up in the mornings. So will see if I get tested for PsA at the end of the month on my next appointment .....

[Caroline]

I have a feeling that my derm department had no interest in diagnosing psa because I was going on mtx which is what they would give me anyway.
However they did diagnose it 'clinically' by my collection of symptoms.

Had they asked 'do you have joint pain' I would have said no. That isn't how my psa has manifested itself, it's all tendon related in my feet and ankles, and the carpal tunnel in the wrist so far. So perhaps I'm in early stages of psa and they aren't bothered as long as they are prescribing drugs for my skin which also work for elsewhere.

I have been told twice (by my GP) I'll see a rheumy but I never have, and begin to suspect that I won't unless symptoms get worse. I have seen podiatrists though.

Yes I'm the same they ask in passing about joint pain and are quick not to ask to much
I'm fortunate so far as my psoriasis has been mainly skin but I suspect I'm experiencing changes in my foot joints when I get up in the mornings. So will see if I get tested for PsA at the end of the month on my next appointment .....

There is no test for PsA....

It is completely done by observing the symptoms and after that it is an educated guess.

[mataribot]

A Dermotologist cannot ethically treat PsA. Unless it's completely obvious, they probably will not forward to a Rheumotologist.