Psoriatic arthritis is getting undiagnosed

[Fred]

This is another one of the those systematic review and meta-analysis articles that looked into prevalence of undiagnosed psoriatic arthritis (PsA) among psoriasis patients, it concluded that there is a high prevalence of undiagnosed PsA in patients with psoriasis and recommended that dermatologists need to screen all patients with psoriasis for PsA.

Quote:

---

Background:
Skin psoriasis precedes the onset of psoriatic arthritis (PsA) in 84% of patients with psoriasis. Dermatologists have an important role to screen psoriasis patients for PsA. The efficiency of PsA screening remains unknown.

Objective:
We sought to determine the point prevalence of undiagnosed PsA in patients with psoriasis using a systematic search of the literature and meta-analysis.

Methods:
pub med, Cochrane, and Embase database searches yielded 394 studies for review. No study aimed to determine the prevalence of undiagnosed PsA in patients with psoriasis. We assumed that the prevalence of newly diagnosed PsA in patients with psoriasis at the time they seek medical care could be a sound estimate of this value. Seven epidemiological studies and 5 studies on PsA screening questionnaires allowed us to clearly identify patients with newly diagnosed PsA and were selected for review.

Results:
The prevalence of undiagnosed PsA was 15.5% when all studies were considered and 10.1% when only epidemiological studies were considered.

Limitations:
Data were obtained from studies not designed to address the question at hand. Heterogeneity was high (I2 = 96.86%), and therefore a random effects model was used.

Conclusion:
The high prevalence of undiagnosed PsA in patients with psoriasis adds to the recommendation that dermatologists need to screen all patients with psoriasis for PsA.

Source: jaad.org

*All 30 authors have received consultant fees from AbbVie.

[jiml]

I agree if there is a high rate of undiagnosed PsA it would be prudent for dermatologists to screen for it, although I suspect the cost of treatments would make diagnosing it prohibitive in a time of cutbacks and increasing drug costs, if you have been referred  with psoriasis and not joint pain


The only screening I have ever had has been a few words at clinic meetings "do you have any joint pain?"  I answer no .......End of discussion .

I think proper screening would be good if that would mean they could halt the joint deterioration. If they can't do that. There is no point just knowing .

[Caroline]

But is it true that there is a vast amount of PsA after psoriasis?
That is a no isn't it?
Isn't it about max 20% or even less who get PSA ?

Still think it is smart of The derms to check for it. But.... It is not their thing, as they watch the skin, not the joints. They are limited by profession.

[Fred]

But is it true that there is a vast amount of PsA after psoriasis?
That is a no isn't it?
Isn't it about max 20% or even less who get PSA ?

Still think it is smart of The derms to check for it. But.... It is not their thing, as they watch the skin, not the joints. They are limited by profession.

Well according to our own latest research in this page: https://psoriasisclub.org/whatispsoriasis.php Psoriasis affects around 1 in 50 people worldwide and around 20% of those will go on to have psoriatic arthritis.

So yes you are right it is low, but as an psoriatic arthritis person myself I wish it had been diagnosed earlier. And yes you are right a dermatologist is more interested in the skin, but here at least they are trialling joint consultations with a dermatologist and a rheumatologist at the same time. I have had one and it's been successfull, I have another in a months time and I must say it's a good step forward but I don't know if other countries are trying this.

[jiml]

But is it true that there is a vast amount of PsA after psoriasis?
That is a no isn't it?
Isn't it about max 20% or even less who get PSA ?

Still think it is smart of The derms to check for it. But.... It is not their thing, as they watch the skin, not the joints. They are limited by profession.

Well according to our own latest research in this page: https://psoriasisclub.org/whatispsoriasis.php Psoriasis affects around 1 in 50 people worldwide and around 20% of those will go on to have psoriatic arthritis.

So yes you are right it is low, but as an psoriatic arthritis person myself I wish it had been diagnosed earlier. And yes you are right a dermatologist is more interested in the skin, but here at least they are trialling joint consultations with a dermatologist and a rheumatologist at the same time. I have had one and it's been successfull, I have another in a months time and I must say it's a good step forward but I don't know if other countries are trying this.

It's not being done at our hospital if you mention joint pain you then get referred to a rheumatologist not a joint meeting though

[Caroline]

But is it true that there is a vast amount of PsA after psoriasis?
That is a no isn't it?
Isn't it about max 20% or even less who get PSA ?

Still think it is smart of The derms to check for it. But.... It is not their thing, as they watch the skin, not the joints. They are limited by profession.

Well according to our own latest research in this page: https://psoriasisclub.org/whatispsoriasis.php Psoriasis affects around 1 in 50 people worldwide and around 20% of those will go on to have psoriatic arthritis.

So yes you are right it is low, but as an psoriatic arthritis person myself I wish it had been diagnosed earlier. And yes you are right a dermatologist is more interested in the skin, but here at least they are trialling joint consultations with a dermatologist and a rheumatologist at the same time. I have had one and it's been successfull, I have another in a months time and I must say it's a good step forward but I don't know if other countries are trying this.

It was not done when I went to the hospital, the rheumatologist knew what he was talking about, but had no clue of what to do next except for MTX.
Had to find out everything myself.

[Fred]

Sounds like what they are trying here could be the way to go then. However I could again be lucky as it's a training hospital that I go to, and it could just be something they are testing out.

[Quest4Cure]

Sounds like what they are trying here could be the way to go then. However I could again be lucky as it's a training hospital that I go to, and it could just be something they are testing out.

Hi Fred,

Check online for psoriasis clinical studies in your area. Many big Pharms post clinical studies in all countries available during the different phases as open or closed studies.I hope there is one in your country close for you.

I have read where the gene marker for PSA has been Identified. Scientists have found a PSA gene marker on what is called a locus. A specific place on a chromosome where genetic variations happen. Scientisits have found a genetic variation or gene marker for psoriatic arthritis on a locus on chromosome 5. Scientists found this marker to make a patient prone to PSA and not Psoriasis. Now it's narrowed down to the IL-23 monoclonal antibody drug is the next step for research for PsA.

Also another med for Psoriasis has been approved in the U.S. IL-17a interleukin pathway 17-A
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody for P. & PSA. Hope it's available for you. I read it can clear P. Patients with 40%-60% coverage in 3-4 weeks.

Side effects are smiling , laughing, wearing shorts & Swim suits, even using less vacuum bags....

Science is bringing greater knowledge & understanding for research by Big pharms around the world.

Good news!

[Fred]

I have read where the gene marker for PSA has been Identified. Scientists have found a PSA gene marker on what is called a locus. A specific place on a chromosome where genetic variations happen. Scientisits have found a genetic variation or gene marker for psoriatic arthritis on a locus on chromosome 5. Scientists found this marker to make a patient prone to PSA and not Psoriasis. Now it's narrowed down to the IL-23 monoclonal antibody drug is the next step for research for PsA.

Merck highlites R&D of anti-interleukin-23

Also another med for Psoriasis has been approved in the U.S. IL-17a interleukin pathway 17-A
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody for P. & PSA. Hope it's available for you. I read it can clear P. Patients with 40%-60% coverage in 3-4 weeks.

Yes we have a lot of information on Cosentyx and it's in our list of Biological Treatments For Psoriasis

As for trials I nearly went on the ASP015K one, but didn't get it because I had been using Bio's for to long. But trials are not something I would normaly go for, and if I did it would be through my hospital.

[Quest4Cure]

I have read where the gene marker for PSA has been Identified. Scientists have found a PSA gene marker on what is called a locus. A specific place on a chromosome where genetic variations happen. Scientisits have found a genetic variation or gene marker for psoriatic arthritis on a locus on chromosome 5. Scientists found this marker to make a patient prone to PSA and not Psoriasis. Now it's narrowed down to the IL-23 monoclonal antibody drug is the next step for research for PsA.

Merck highlites R&D of anti-interleukin-23

Also another med for Psoriasis has been approved in the U.S. IL-17a interleukin pathway 17-A
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody for P. & PSA. Hope it's available for you. I read it can clear P. Patients with 40%-60% coverage in 3-4 weeks.

Yes we have a lot of information on Cosentyx and it's in our list of Biological Treatments For Psoriasis

As for trials I nearly went on the ASP015K one, but didn't get it because I had been using Bio's for to long. But trials are not something I would normaly go for, and if I did it would be through my hospital.

Hi
Have you tried cosentyx? Just curious when I see a pic of your skin and I can't help but worry why nothing seems to help clear up you Psoriasis.Im so very sorry you seem to go thru so much. I was hospitalized with P. As a child and their treatment was UVB and occlusion. Treatment has come a long way since then.
THANKX for the thread referrals have read a lot of threads clinical studies posted. You do a great job getting as mich info as you can on all the bio treatments as well as the plethora of natural treatments.
Diet has never had an effect on my P. It's good to eat healthy & clean for good health period. No scientifically proof on P. Clearing.some P. Patience swear it cleared the rid skin Yet I see your skin and I know you have tried many treatments BiOS see can quit working after a time and scientists are now doing studies on that.
I keep trying to help you find something for relief.
have you tried to add a water conditioner / softener on the home filter water system and black light and filters . It's made a big difference in our Psoriasis.
I hope you are better soon.
Thank you for all you contributions.

Kind Regards
Quest4Cure