Fumaderm to Methotrexate switch, advice?

[ccarr06]

Just to clarify the doseage I've been given, it's 2.5 the first week. Then I have to get bloods done, then up to 5 mg, and then 10mg. I will be back with the consultant then who will up the doseage as long as my results are fine.

Thanks    so it will be a steady build up I understand now  

Exactly, they just want to make sure I don't have any adverse reaction, probably being more cautious because of the IgA nephropathy.

[jiml]

Just to clarify the doseage I've been given, it's 2.5 the first week. Then I have to get bloods done, then up to 5 mg, and then 10mg. I will be back with the consultant then who will up the doseage as long as my results are fine.

Thanks    so it will be a steady build up I understand now  

Exactly, they just want to make sure I don't have any adverse reaction, probably being more cautious because of the IgA nephropathy.

Yes it's a wise move, better to be safe with a history of kidney disease

[Vincent]

I was in a similar situation with Fumaderm - started last year but could progress further that 3 2nd dosage tablets/ day - liver probs and then severe outbreak of PS & itching ......now on nex 10 mg and it appears to have kicked in ......see my Derm later in October  &  see the next steps forward

[ccarr06]

I was in a similar situation with Fumaderm - started last year but could progress further that 3 2nd dosage tablets/ day - liver probs and then severe outbreak of PS & itching ......now on nex 10 mg and it appears to have kicked in ......see my Derm later in October  &  see the next steps forward

Hi Vincent,
I only seen your post now. Can I ask how you got on? I'm on 15mg of mtx but my skin hasn't cleared at all. It's actually gotten worse I'm hoping it will start to kick in soon

[Caroline]

Hopefully It will kick in soon ccar.
You know my hesitations with MTX, but as long as you can deal with it...

Remember, there is a new DMF medication in the form of Skilarence. This has no MEF, like Fumaderm has, and might do better. A thought to keep in your mind.

[Vincent]

Currently on four 2.5 mg ( 10 mg) Methotrexate dose once per week since 13/09/2017 - currently no probs liver status ok ...PS has reduced back to same as with FUM .......see my consultant this Weds ( 8 Nov 2017 ) will raise Caroline's points with my Derm Consultant

[Vincent]

Hi Caroline - regarding Skilarence is this gentle on the Liver ? Thanks Vince

[Caroline]

Hi Caroline - regarding Skilarence is this gentle on the Liver ? Thanks Vince

If basically you liver is ok. Then DMF, the only and working substance in Skilarence, has no interaction with liver nor kidneys. That is why it is such great stuff, but not seen by dermatologists.
It may be different if you already have problems with your liver, but that holds even more for MTX.

Fumaderm may have an interaction with your liver because it contains MEF (mono ethyl fumarate) which is toxic.

[Fred]

Hi Caroline - regarding Skilarence is this gentle on the Liver ? Thanks Vince

If basically you liver is ok. Then DMF, the only and working substance in Skilarence, has no interaction with liver nor kidneys. That is why it is such great stuff, but not seen by dermatologists.
It may be different if you already have problems with your liver, but that holds even more for MTX.

Fumaderm may have an interaction with your liver because it contains MEF (mono ethyl fumarate) which is toxic.

Skilarence

[Vincent]

Thanks