Methotrexate please help

[D Foster]

I was on MTX for 9 years , oral then injection and I had side effects that just got to bad so went on to injections and the same thing happened again. Never got complete clearance by a long way though it did keep both the P and PsA under control to an acceptable level. It now sounds like you are losing the battle with MTX and need to move on to other treatments and I would say bio's are the way to go but how your health system works I don't know, in UK you would be eligible to move on to bio's I would say.
We are all different so treatments work in different ways for each person but Cosentyx. would seem to be a very good one to go on though I am on Stelara and it's been life changing , works well for me on P and PsA though I am starting to lose the battle a little now and Cosentyx is the one that they have talked about which for most people seems to work much better for the PsA side than Stelara.

[fialstar]

Has anyone had the side effect of depressed or volatile moodswings while taking oral mtx?
Apparently uncommon, but I seem to have lost control of my ability to maintain calm and this is listed as one of the possible effects of this medication.
Just wondering how many others may have experienced this?

[JohnB]

Has anyone had the side effect of depressed or volatile moodswings while taking oral mtx?
Apparently uncommon, but I seem to have lost control of my ability to maintain calm and this is listed as one of the possible effects of this medication.
Just wondering how many others may have experienced this?

Hi Fialstar
No it's not something I have come across personally, but then I have not been on MTX that long. I am normally so laid back I'm horizontal, it winds Mrs John up something chronic. 
What I would say is if this is not you then it will be the MTX no matter how uncommon the side effect is.

[jiml]

I never had mood swings when I was on it but was constantly nauseous and got to dread Mondays coming round and got quite depressed and had to force myself to take the tablets ...so depression was a side effect for me but volatile mood swings weren't
I would definitely tell the dermatologist and ask for something else if it's not the normal you

[Caroline]

My experiences, long ago, were alike Jim’s. I did not have mood swings, but I felt at all not good, which influenced my normally sunny nature. And I would not have been surprised if it would have led to a depression. But it never came so far as I decided to stop with it, despite what the rheumatologist said, and later on this proved to the the right decision as I found a much better treatment. It resulted as a whole in a negative attitude of me towards rheumatologist, as after 15 years they only know one treatment to start with and that is MTX.. they did not learn, and hide behind the rules.
I think this is way against their oath in helping people the best they can, as they can do much better, but do not seem to learn from the past.

[Fred]

Has anyone had the side effect of depressed or volatile moodswings while taking oral mtx?
Apparently uncommon, but I seem to have lost control of my ability to maintain calm and this is listed as one of the possible effects of this medication.
Just wondering how many others may have experienced this?

Yes when I was briefly on it a long time ago apart from it making me sick all the time it did make me depressed. On trying it again via injection a few years ago I started getting very bad mood swings, it was not like me to snap at Mrs Fred the way I did. But once I stopped taking it everything was fine again.

[D Foster]

Not had anything like mood swings but it did start to get to me when the side effects got bad so if I asked Mrs Dave she may say that I was raggy at the time. Have a word with the consultant ,sounds like it's time to go bio's .